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Actual RESEARCH (not hearsay) on Aspartame and Safety

Posted by Joel Marion

Alright, so I ended up causing quite a stir with my post about artificial sweeteners yesterday, and today I’m back to share some research as promised. When talking artificial sweeteners, there are generally two major concerns:

1. Safety
2. Fat Loss

Let’s discuss the research surrounding both. First up, safety.

1. Butchko HH et al. Aspartame: review of safety. Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 2):S1-93.

In this 2002 paper, over 20 years since the food additive was approved by the FDA, a comprehensive review of all aspartame research to date concluded that aspartame is indeed safe when consumed by normal humans in acceptable amounts (more on acceptable amounts in a minute).

2. Magnuson BA, Burdock GA, Doull J, et al. (2007). Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit. Rev. Toxicol. 37 (8): 629-727.

Now more than 25 years later, another safety evaluation found that the weight of existing scientific evidence indicates that aspartame is safe at current levels of consumption as a non-nutritive sweetener.

3. Gallus S; Scotti L, Negri E, Talamini R, Franceschi S, Montella M, Giacosa A, Dal Maso L, La Vecchia C. (January 2007). Artificial sweeteners and cancer risk in a network of case-control studies. Annals of Oncology 18 (1): 40-44.

This study analyzing over 15 years of research showed a clear cut “lack of association between saccharin, aspartame and other sweeteners and the risk of several common cancers”

4. Lim U, Subar AF, Mouw T, et al. Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies. Cancer Epidemiology Biomarkers Prevention 2006; 15.

In 2006, the US National Cancer Institute concluded in a study of over a HALF MILLION men and women aged 50 to 69 that there was no statistically significant link between aspartame consumption and leukemias, lymphomas or brain tumors.

A study of over a half million HUMANS showing no statistically significant link between aspartame and cancer, and three other 15-25 year comprehensive reviews of ALL the available research, all finding that aspartame is indeed safe when consumed in acceptable amounts.

That sure seems to ring more factual than someone’s “conspiracy” website to me.

Now, I could have sat here and listed out a couple hundred papers showing no statistical significance, but instead I chose to list the review papers who already included that data in their 20+ year review.

So, you’re probably wondering what’s “acceptable”?

You’re bound to find this interesting…

Based on all available research, scientists first determine the maximum amount of a food ingredient that can be safely consumed daily over a person’s lifetime. Then, just in case they screwed up by 10,000%, they divide this number by 100 and call that the ADI (acceptable daily intake).

Just in case you didn’t get that, the ADI is actually 100 TIMES LESS than what has been scientifically determined to be safe, as an extremely conservative precautionary measure.

So what’s the ADI for aspartame?

The ADI for aspartame has been set at 50mg/kg of body weight (again, this is 100 times less than what has been determined safe).

But to even reach the ultra conservative ADI, a 150-pound adult would have to consume about 20 12-oz. diet carbonated soft drinks, or 33 8-oz. servings of powdered soft drink, or 42 4-oz. servings of gelatin, or 97 packets of tabletop sweetener each and every day.

And people are still worrying about safety issues based on a couple studies done on RATS being fed the aspartame equivalent of up to 2,000 cans of Diet Coke daily. No, that is NOT a misprint.

Before going any further, let me just clarify my recommendations.

1. I do not think non-nutritive sweeteners, particularly aspartame as it’s perhaps the most studied nutrient of all time, are the devil.

2. Despite the ADI, I do not recommend anyone drink 20 diet soft drinks or use 97 packets of Equal daily.

3. If you are drinking a caffeinated beverage, such as Diet Coke, etc, then I would recommend you limit your intake to one can per day.

4. If going with something non-caffeinated, you can be a little more liberal, but the bulk of your daily fluid intake should still come in the form of good old fashion water.

5. In Summary: Drink at least a half gallon of water daily, but feel free to enjoy other non-calorie drinks in moderation (1-3 beverages per day)

6.  Lastly, if you personally as an individual experience adverse reactions like headaches, dizziness, etc, due to the use of aspartame, then don’t use it.  Just realize that you fall into .0000001% of the population and shouldn’t preach your personal experience as truth for all.  One of my friends is allergic to chocolate, but she doesn’t go around telling everyone else that it’s poison.

So it looks like my recommendations are actually 1,000 times less than what has been determined safe, and I’m pretty comfortable making that recommendation.

Alright, this post is already going longer than I anticipated, so I’m going to save the research on non-nutritive sweeteners and weight loss for tomorrow.

At least 100 comments and I’ll be back tomorrow with that data (which you’ll probably find even more interesting).

In clarity and moderation,

Joel

P.S.  My friend Isabel kind of bashes artificial sweeteners in the below video, and while I do NOT agree with that stance, I do agree with just about everything else she shares for losing up to 10% of your unwanted body fat in the next 30 days.  You can check it out here for some eye-opening, actionable tips:

How to lose up to 10% of your unwanted body fat in the next 30 days <——- Click here

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277 comments - add yours
Reply  |  Quote

hi joel, thx for the dicussion and all your info.
as you I wish to read the original research before (dis)believing a story. sadly many articles aren’t open to everyone, I often can only read the abstracts,but that gives me an impression at least.
I now know there is a lot of research that didn’t find a connection, I haven’t found the articles that did find a connection (even if the dose was impossible high) and you mentioned them but didn’t give the source like you did with the others, (maybe the only mistake I’ve seen you make yet),can you give them?

futhermore I have a lot of respect for what you do and the way you do it, keepup the good work,greetings richard, the netherlands

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Back about half a year ago you did this subject and the post made laugh then and the still make me laugh. I love the “rat poison is safe to an extent” arguement. Yes everything can kill you if you consume too much. This includes water, fat soluble vitamines (adek), cafeinne, pain killers like advil or tylenol and yes both rat poison and artificial sweeteners. What is important is the dose and also if the benefits are worth it. Unless you need a blood thinner there is NO benefit too rat poison (ie Warfrin) so why would you want to take it? That would just be stupid. However artificial sweeteners have the benifit of sweetening your drinks without adding calories. It can help curve sugar cravings which helped me get rid of my sugar addiction and loose 40 lbs. And it does all this with no proven adverse causes if you drink one or two cans of diet pop a day

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Great job, Joel!

Would you also look into the effects of artificial sweeteners on insulin response?
That may be of huge relevance for the health of the pancreas and developing diabetes.

Look forward to it.
Nic

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Dude…thanks for sharing the REAL science behind artificial sweetners!

In general, I stay away from most processed foods, sugar and artificial sweetners anyway.

But, it’s nice to know that if I want to sweeten something I’m eating AND I want to limit the calories I’m consuming, then it’s OK to grab the artificial stuff.

I guess the old saying still holds true…”Almost anything in moderation is probably OK”…especially when you talk about sugar or artificial sweetners.

Wishing you the best,

~ Pete

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I started suffering from migranes several years back and went to many doctors and took medications due to the pain and disruption in my daily life because of these episodes. Subsequently nothing worked, the headaches were more frequent and I started having problems with my prostrate. After doing everything i could through my DR I started to review what i was ingesting. My boss would supply sodas at work to keep everyone caffinated and awwake and my favorite was Diet Coke, some days I would drink four or five and chew gum all day.
When I cutout the soda the migranes became less frequent, when I read the ingredients i decided to stay away from aspartame. It was everywhere and in everything and when I emptied my cabinets of anything that had a trace of it, my migranes stopped all together and within several weeks my prostrate was back to normal. The scary thing is it is everywhere and a safe level is hard to maintain when it literally is in anything diet and lots that isnt. Gum even had aspartame. I think you need to discuss how the body breaks this chemical down and what it turns into and how long you store it. That may raise some eyebrows.

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@ Gabriela:
Better IMO, natural product :)

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@ Tim:

Well, you can go the other way around. Can tou prove the link between Aspartam and cancer? Do you have any study that actually prove it? Everything is not “safe when consumed by normal humans in none acceptable amounts” even water. It’s just a way that scientific speak.

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I said it before and I’ll say it again.
I do not trust the makers of “artificial” products. be it coloring, flavouring or sweeteners or anything else for that matter.
have they done any studies on how artificial sweeteners affect our brain function?
I know people who thought they had ADD… then they stopped consuming diet pop and anything else that has artificial ingredients (mostly sweeteners in this case) and viola! all of a sudden they can focus and behave like normal people (not an over energized monkey (for a lack of a better example, no offence to anyone)
it’s very hard to stick to this life style in today’s artificially abundant world. but I do what I can.
for starters, i stay away from anything that i can replace with natural ingredients.

a lot of people do like splenda and all that jazz, and i found that its useless trying to convince someone to go one way or another.
in the end its our choice of what we put in our body and we will suffer (or enjoy) the consequences later on in life.

the point is to get back to basics. we have so much crap in and around us that its especially difficult to stay natural. we are striving to consume good quality ingredients to stay healthy and in my books artificial sweeteners are as far from that category as they can be.

as always, i enjoyed your post. keep ‘em coming, Joel.

Have a great weekend.

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@ Tim:Heh you are taking rat poison every day either through the sun or maybe in supplement form as vitamin D is a popular rat poison ;)

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I just love it when they take a small animal, feed it 1000 times the quantity a person consumes and if it dies or gets sick then doom the stuff. Neyt step should be, they give a rat 1.5 liters of water and if it dies they decide water is bad for us… anyway,even after reading this I wont take more than 1-2 pills (they sell it in this form instead of packets) a day (closer to 1) but I will feel perfectly safe with my intake.

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All I can say is WOW! I remember this research years back when they outlawed cyclamates. I didn’t believe the scare stories about that but I did/do have a bad opinion of aspartame. I am one of those in the low percentage group who can’t tolerate it. Two swallows of a drink sweetened with aspartame & I get stomach pains & am ready to throw up. So not using it is a no-brainer for me. I use stevia now.

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Check out this article by Dr. Mercola and then try to convince yourself that aspartame is safe! http://articles.mercola.com/sites/articles/archive/2010/07/31/aspartame-update.aspx

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I’m sure that the sugar companies don’t have any vested interest in fueling this debate at all…

Just be careful out there; it’s dangerous to live, you’ll probably die.

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Okay, no cancer (as of now), but what about other side effects? I’ve found that I get lightheaded,and have a weird brief vertigo episode followed by a loud buzz/hum in my ears. If I dilute a diet with a regular soda about 1/2 and 1/2 I can deal with it, but otherwise, even one can gives me lightheadedness.

Wonder about other health effects. Can you research those?

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Most of the issues with aspartame that I have heard of do not involve cancerous tumors. It’s more in line with brain seizures, panic attacks, and allergic reactions. I personally know an epilectic that started having seizures again after his wife left (he had started drinking her sugar free soda which she had left behind). I personally know others who have gone to the doctor because of anxiety attacks. Take away the sugar free soda, no need for medication. And others have lost weight just by switching their diet sodas for regular. Many things will cause cancer when taken in excess, so I wouldn’t use these research reports as an indication of relative safety. It’s only looking at one facet.

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@ Krista:
Oh good somebody else pointed out this idiocy. I was going to do it but… thanks Krista you just saved me 5 minutes.

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Hi Joel

I read through all your info when it first came out and was so glad to actually have some citable evidence to show that there is no proven link between artificial sweetners and cancer, diabetes, etc, etc (mind you when I passed it on to the cynics they still didn’t believe it of course!).

Anyway, I came across a report by Belinda Benn (not sure if you know of her, but came through same link from where I first got onto your XFLD). She says, quote, unquote:

“Synthetic sweeteners can slow down fat metaboloism and sabotage our weight loss. Research also shows that daily consumtion of diet soda makes us at higher risk of developing type 2 diabetes” The paper cited on the research is:
Jennifer A Nettleton, Pamela L Lutsey, Youfa Wang, Joao A Lima, Erin D Michos & David R Jacobs, Jr. Diet Soda Intake and Risk of Incident Metabolic Syndrome and Type 2 Diabetes in the Multi Ethic Study of Atherosclerosis (MESA). American Diabetes Association, http://care.diabetesjournals.org/content/32/4/688.full#ref-5

Is this anythingt o be worried about?

I would like to try Stevia but am living in the Netherlands at the moment and find anything like this hard to source. I will continue my search, but in the meantime would be very interested to hear your response to this article, so I can rest easy again using those little blue packets at work!

Thanks
Bec

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@ Keith:
I absolutely agree with Kayla K. Anything natural is usually good for the body. Any more than five ingredients I usually try to stay away from. Mind you, I’d rather consume regular sugar than artificial sweetener. Dr. Mercola has a LOT to say about that… so if you’re interested in researching further I suggest you read some of his research. Stay blessed, strong, and healthy, C

Reply  |  Quote

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Unfortuneately Joel, the equivalent to 2000 cans of coke a day makes sense. Rats can process aspartame, in humans in sticks around. So to maintain the same levels in a rat body as in a human body, they need to have the rats injest more. Plus, research has shown that you can lose up to 50 percent or more of your brain cells before you realize that any damage has occurred. There are other safe, non-engineered sweeteners out there that actually have health benefits, like Xylitol. I’m amazed you don’t expand more on the other options out there. Also, no independent testing has been done to confirm this research as companies would need to obtain permission from the companies manufacturing these products prior to being able to do so. Meaning, if research cannot be duplicated by an independent outside party, then by scientific methodology, it is just as much ‘hearsay’ and ‘misinformed’ as every other person posting on this topic.

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I’ll admit I have been following the wrong info based on your research. I appreciate you having the guts to be an individualist within your field.

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As for me however, I will pretty much stick with adding a bit of Stevia and sometimes Xylitol. They satisfy my desire for sugar and I am 100% confident in their efficacy. I have lost 2″ of my waist following your high protein, low carb and natural food regime and have done it with very little exercise.

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My experience is somewhat related to the experience in this article. After discontinuing use of any artificial sweetners, some of my symptoms disappeared, but some remain to this day, almost 20 yrs later. Is discontinuing use enough? How does one detox, rid fat deposits of stored toxins? I have taken numerous natural suppliments that help some, but still feel that I’m dealing with too many toxins in my system. Thanks for any replies.
@ Epiphanio D’Souza:

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